Characterization of the bruise healing process using pulsed photothermal radiometry

Luka Vidovič; Matija Milanič; Lise L. Randeberg; Boris Majaron

doi:10.1117/12.2032490

18 June 2013 Characterization of the bruise healing process using pulsed photothermal radiometry

Luka Vidovič, Matija Milanič, Lise L. Randeberg, Boris Majaron

Proceedings Volume 8801, Novel Biophotonic Techniques and Applications II; 880104 (2013) https://doi.org/10.1117/12.2032490
Event: European Conferences on Biomedical Optics, 2013, Munich, Germany

Abstract

An analytical model of mass diffusion and biochemical transformation kinetics in bruise development and healing process was recently developed in order to simulate bruised skin color at various time points and enable objective determination of the time of injury. However, parameters of the model were not determined directly. Instead, biologically plausable values were applied in prior analyses. Pulsed photothermal radiometry (PPTR) allows noninvasive determination of the laser-induced temperature depth profile in human skin. We have applied this technique to characterize dynamics of extravasated hemoglobin concentration profile evolution. By applying Monte Carlo simulation of laser energy deposition and simulation of PPTR signal, a more exact comparison with measured temperature profiles is possible. We show that PPTR depth profiling can be used to derive rather accurate estimates of the hemoglobin mass diffusivity, hemoglobin degradation time, as well as approximate skin geometry. This enables assessment of the bruise healing dynamics and could offer a valuable addition to existing bruise age determination techniques.

Citation Download Citation

Luka Vidovič, Matija Milanič, Lise L. Randeberg, and Boris Majaron "Characterization of the bruise healing process using pulsed photothermal radiometry", Proc. SPIE 8801, Novel Biophotonic Techniques and Applications II, 880104 (18 June 2013); https://doi.org/10.1117/12.2032490

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