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Evaluation of visual field (VF) is important for clinical diagnosis and patient monitoring. The current VF methods are
subjective and require patient cooperation. Here we developed a novel objective perimetry technique based on the pupil
response (PR) to multifocal chromatic stimuli in normal subjects and in patients with glaucoma and retinitis pigmentosa
(RP). A computerized infrared video pupillometer was used to record PR to short- and long-wavelength stimuli (peak
485 nm and 620 nm, respectively) at light intensities of 15-100 cd-s/m2 at thirteen different points of the VF. The RP
study included 30 eyes of 16 patients and 20 eyes of 12 healthy participants. The glaucoma study included 22 eyes of 11
patients and 38 eyes of 19 healthy participants. Significantly reduced PR was observed in RP patients in response to
short-wavelength stimuli at 40 cd-s/m2 in nearly all perimetric locations (P <0.05). By contrast, RP patients
demonstrated nearly normal PR to long-wavelength in majority of perimetric locations. The glaucoma group showed
significantly reduced PR to long- and short-wavelength stimuli at high intensity in all perimetric locations (P <0.05). The
PR of glaucoma patients was significantly lower than normal in response to short-wavelength stimuli at low intensity
mostly in central and 20° locations (p<0.05). This study demonstrates the feasibility of using pupillometer-based
chromatic perimetry for objectively assessing VF defects and retinal function and optic nerve damage in patients with
retinal dystrophies and glaucoma. Furthermore, this method may be used to distinguish between the damaged cells
underlying the VF defect.
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