Third therapeutic spectral window for deep tissue imaging

Laura A. Sordillo; Sebastião Pratavieira; Yang Pu; Kaliris Salas-Ramirez; Lingyan Shi; Lin Zhang; Yury Budansky; R. R. Alfano

doi:10.1117/12.2040604

17 March 2014 Third therapeutic spectral window for deep tissue imaging

Laura A. Sordillo, Sebastião Pratavieira, Yang Pu, Kaliris Salas-Ramirez, Lingyan Shi, Lin Zhang, Yury Budansky, R. R. Alfano

Author Affiliations +

Proceedings Volume 8940, Optical Biopsy XII; 89400V (2014) https://doi.org/10.1117/12.2040604
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Light at wavelengths in the visible and near-infrared (NIR) regions (650 nm – 1,350 nm) is used in numerous medical applications. The NIR region between 650 nm and 950 nm, known as the first optical window, allows for deeper depth penetration in tissue than in the visible region due to a reduction in absorption. There also exists a second NIR optical window with wavelengths from 1,100 nm to 1,350 nm. Longer wavelengths above 1,350 nm were ignored due to major water absorption and lack of 2D photodetectors. In this study, a new therapeutic spectral window with wavelengths between 1,600 nm and 1,870 nm is reported. This third optical window can be used for imaging more deeply into tissue due to a reduction in scattering. In this paper, light attenuation from 400 nm to 2,000 nm, including all three optical windows, was measured. 200 micron slices of normal and benign prostate and breast tissues were studied. The total attenuation lengths (l_t) of light were obtained. The attenuation length of malignant and normal tissue in the third optical window was larger than in the first and second therapeutic windows. Optical images of chicken tissue over three black wires were also obtained using the third optical window.

Citation Download Citation

Laura A. Sordillo, Sebastião Pratavieira, Yang Pu, Kaliris Salas-Ramirez, Lingyan Shi, Lin Zhang, Yury Budansky, and R. R. Alfano "Third therapeutic spectral window for deep tissue imaging", Proc. SPIE 8940, Optical Biopsy XII, 89400V (17 March 2014); https://doi.org/10.1117/12.2040604

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available