Effects of cyclophosphamide on laser immunotherapy for the treatment of metastatic cancer

Cody F. Bahavar; Joseph T. Acquaviva III; Sheyla Rabei; Allie Sikes; Robert E. Nordquist; Tomas Hode; Hong Liu; Wei R. Chen

doi:10.1117/12.2040954

27 February 2014 Effects of cyclophosphamide on laser immunotherapy for the treatment of metastatic cancer

Cody F. Bahavar, Joseph T. Acquaviva III, Sheyla Rabei, Allie Sikes, Robert E. Nordquist, Tomas Hode, Hong Liu, Wei R. Chen

Author Affiliations +

Proceedings Volume 8944, Biophotonics and Immune Responses IX; 894408 (2014) https://doi.org/10.1117/12.2040954
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Laser immunotherapy (LIT) is an innovative cancer modality that uses laser irradiation and immunological stimulation to treat late-stage, metastatic cancers. The current mode of operation in LIT is through interstitial laser irradiation. Although LIT is still in development, recent clinical trials have shown that it can be used to successfully treat patients with late-stage breast cancer and melanoma. Cyclophosphamide is a chemotherapy drug that suppresses regulatory T cells when used in low doses. In this study tumor-bearing rats were treated with LIT using an 805-nm laser with a power of 2.0 W and low-dose cyclophosphamide. Glycated chitosan was used as an immunological stimulant. The goal was to observe the effects of different doses of cyclophosphamide in addition to LIT on the survival of the tumor-bearing rats.

Citation Download Citation

Cody F. Bahavar, Joseph T. Acquaviva III, Sheyla Rabei, Allie Sikes, Robert E. Nordquist, Tomas Hode, Hong Liu, and Wei R. Chen "Effects of cyclophosphamide on laser immunotherapy for the treatment of metastatic cancer", Proc. SPIE 8944, Biophotonics and Immune Responses IX, 894408 (27 February 2014); https://doi.org/10.1117/12.2040954

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