Mapping local anisotropy axis for scattering media using backscattering Mueller matrix imaging

Honghui He; Minghao Sun; Nan Zeng; E. Du; Yihong Guo; Yonghong He; Hui Ma

doi:10.1117/12.2038979

4 March 2014 Mapping local anisotropy axis for scattering media using backscattering Mueller matrix imaging

Honghui He, Minghao Sun, Nan Zeng, E. Du, Yihong Guo, Yonghong He, Hui Ma

Proceedings Volume 8952, Biomedical Applications of Light Scattering VIII; 89521B (2014) https://doi.org/10.1117/12.2038979
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Mueller matrix imaging techniques can be used to detect the micro-structure variations of superficial biological tissues, including the sizes and shapes of cells, the structures in cells, and the densities of the organelles. Many tissues contain anisotropic fibrous micro-structures, such as collagen fibers, elastin fibers, and muscle fibers. Changes of these fibrous structures are potentially good indicators for some pathological variations. In this paper, we propose a quantitative analysis technique based on Mueller matrix for mapping local anisotropy axis of scattering media. By conducting both experiments on silk sample and Monte Carlo simulation based on the sphere-cylinder scattering model (SCSM), we extract anisotropy axis parameters from different backscattering Mueller matrix elements. Moreover, we testify the possible applications of these parameters for biological tissues. The preliminary experimental results of human cancerous samples show that, these parameters are capable to map the local axis of fibers. Since many pathological changes including early stage cancers affect the well aligned structures for tissues, the experimental results indicate that these parameters can be used as potential tools in clinical applications for biomedical diagnosis purposes.

Citation Download Citation

Honghui He, Minghao Sun, Nan Zeng, E. Du, Yihong Guo, Yonghong He, and Hui Ma "Mapping local anisotropy axis for scattering media using backscattering Mueller matrix imaging", Proc. SPIE 8952, Biomedical Applications of Light Scattering VIII, 89521B (4 March 2014); https://doi.org/10.1117/12.2038979

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KEYWORDS

Tissues

Anisotropy

Backscatter

Scattering media

Biomedical optics

Monte Carlo methods

Scattering

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