Synthesis of folate receptor-targeted photosensitizers for photodynamic therapy

Yanyan Fang; Xiaopu Wang; Qianli Zou; Yuxia Zhao; Feipeng Wu

doi:10.1117/12.2071756

18 November 2014 Synthesis of folate receptor-targeted photosensitizers for photodynamic therapy

Yanyan Fang, Xiaopu Wang, Qianli Zou, Yuxia Zhao, Feipeng Wu

Proceedings Volume 9268, Optics in Health Care and Biomedical Optics VI; 92680O (2014) https://doi.org/10.1117/12.2071756
Event: SPIE/COS Photonics Asia, 2014, Beijing, China

Abstract

A series of amphiphilic benzylidene cycloalkanes ketone photosensitizers C1-C4 with or without folate receptor-targeted agent were designed and synthesized. Their photophysical properties and in vitro photodynamic therapy (PDT) effects were studied. The results showed that all compounds exhibited appropriate lipid-water partition coefficients and high reactive oxygen yields. The introduction of the folate receptor-targeted agent had no obvious influence on the basic photophysical & photochemical properties of C2 and C4 compared to those of their corresponding prototype compounds (C1 and C3). In vitro studies were carried out using MCF-7 cells (FR+), Hela cells (FR+) and A549 cells (FR-), which represented different levels of folate receptor (FR) expression. All of C1-C4 showed low dark toxicity and superior PDT effects compared with the clinical drug PSD-007 (a mixture of porphyrins). What’s more, folate receptor-targeted photosensitizers (C2 and C4) achieved higher accumulation and more excellent PDT effects in MCF-7 cells (FR+) and Hela cells (FR+) than photosensitizers (C1 and C3) without folate receptor-targeted agent and PSD-007. The photocytotoxicity of these photosensitizers showed no obvious differences in A549 cells (FR-).

Citation Download Citation

Yanyan Fang, Xiaopu Wang, Qianli Zou, Yuxia Zhao, and Feipeng Wu "Synthesis of folate receptor-targeted photosensitizers for photodynamic therapy", Proc. SPIE 9268, Optics in Health Care and Biomedical Optics VI, 92680O (18 November 2014); https://doi.org/10.1117/12.2071756

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available