The stepwise multi-photon activation fluorescence guided ablation of melanin

Zhenhua Lai; Zetong Gu; Charles DiMarzio

doi:10.1117/12.2076837

26 February 2015 The stepwise multi-photon activation fluorescence guided ablation of melanin

Zhenhua Lai, Zetong Gu, Charles DiMarzio

Proceedings Volume 9303, Photonic Therapeutics and Diagnostics XI; 93030N (2015) https://doi.org/10.1117/12.2076837
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Previous research has shown that the stepwise multi-photon activation fluorescence (SMPAF) of melanin, activated and excited by a continuous-wave (CW) mode near infrared (NIR) laser, is a low-cost and reliable method for detecting melanin. We have developed a device utilizing the melanin SMPAF to guide the ablation of melanin with a 975 nm CW laser. This method provides the ability of targeting individual melanin particles with micrometer resolution, and enables localized melanin ablation to be performed without collateral damage. Compared to the traditional selective photothermolysis, which uses pulsed lasers for melanin ablation, this method demonstrates higher precision and lower cost. Therefore, the SMPAF guided selective ablation of melanin is a promising tool of melanin ablation for both medical and cosmetic purposes.

Citation Download Citation

Zhenhua Lai, Zetong Gu, and Charles DiMarzio "The stepwise multi-photon activation fluorescence guided ablation of melanin", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93030N (26 February 2015); https://doi.org/10.1117/12.2076837

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