Longitudinal in vivo transcutaneous observation of Raman signals from breast cancer during chemotherapy in small animal model

Myeongsu Seong; NoSoung Myoung; Sang-Youp Yim; Jae G. Kim

doi:10.1117/12.2079279

26 February 2015 Longitudinal in vivo transcutaneous observation of Raman signals from breast cancer during chemotherapy in small animal model

Myeongsu Seong, NoSoung Myoung, Sang-Youp Yim, Jae G. Kim

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Proceedings Volume 9303, Photonic Therapeutics and Diagnostics XI; 93032U (2015) https://doi.org/10.1117/12.2079279
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Because mammography, the gold standard of breast cancer screening and monitoring treatment efficacy, has limitations, there is a necessity to have a new method for breast cancer patients. Raman spectroscopy is considered as one of the best alternative approaches due to its ability of visualizing (bio)chemical information of a matter. In this study, we hypothesized that the change of biochemical composition occurs earlier than morphological change in breast cancer during chemotherapy, and attempted to prove it by employing fiber-optic Raman spectroscopy for longitudinal Raman measurement in small animal breast cancer model. To confirm the hypothesis, we measured Raman spectra of a tumor breast and the contralateral breast during chemotherapy for 4 fisher 344 female rats longitudinally. Principal component analysis and Raman spectral differences between breast tumor and contralateral normal breast did not show a clear difference between them which may have been caused by interference from skin. Thus, spatially-offset Raman spectroscopy will be employed in order to acquire the Raman signal directly from tumor while suppressing Raman signal from skin for the future study.

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Myeongsu Seong, NoSoung Myoung, Sang-Youp Yim, and Jae G. Kim "Longitudinal in vivo transcutaneous observation of Raman signals from breast cancer during chemotherapy in small animal model", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93032U (26 February 2015); https://doi.org/10.1117/12.2079279

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KEYWORDS

Raman spectroscopy

Breast

Breast cancer

Tumors

Fiber optics

Principal component analysis

Animal model studies

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