Ideal flushing agents for integrated optical acoustic imaging systems

Jiawen Li; Hataka Minami; Earl Steward; Teng Ma; Dilbahar Mohar; Claire Robertson; K. Kirk Shung; Qifa Zhou; Pranav M. Patel; Zhongping Chen

doi:10.1117/12.2074696

26 February 2015 Ideal flushing agents for integrated optical acoustic imaging systems

Jiawen Li, Hataka Minami, Earl Steward, Teng Ma, Dilbahar Mohar, Claire Robertson, K. Kirk Shung, Qifa Zhou, Pranav M. Patel, Zhongping Chen

Author Affiliations +

Proceedings Volume 9303, Photonic Therapeutics and Diagnostics XI; 93032Z (2015) https://doi.org/10.1117/12.2074696
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

An increased number of integrated optical acoustic intravascular imaging systems have been researched and hold great hope for accurate diagnosing of vulnerable plaques and for guiding atherosclerosis treatment. However, in any intravascular environment, vascular lumen is filled with blood, which is a high-scattering source for optical and high frequency ultrasound signals. Blood must be flushed away to make images clear. To our knowledge, no research has been performed to find the ideal flushing agent that works for both optical and acoustic imaging techniques. We selected three solutions, mannitol, dextran and iohexol, as flushing agents because of their image-enhancing effects and low toxicities. Quantitative testing of these flushing agents was performed in a closed loop circulation model and in vivo on rabbits.

Citation Download Citation

Jiawen Li, Hataka Minami, Earl Steward, Teng Ma, Dilbahar Mohar, Claire Robertson, K. Kirk Shung, Qifa Zhou, Pranav M. Patel, and Zhongping Chen "Ideal flushing agents for integrated optical acoustic imaging systems", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93032Z (26 February 2015); https://doi.org/10.1117/12.2074696

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Optical coherence tomography

Blood

Intravascular ultrasound

Imaging systems

Acoustics

Signal attenuation

In vivo imaging

Show All Keywords

Keywords/Phrases

Search In:

Publication Years