Photonic monitoring of chitosan nanostructured alginate microcapsules for drug release

Deepak Kumar Khajuria; Manish C. Konnur; Ramakrishna Vasireddi; D. Roy Mahapatra

doi:10.1117/12.2084966

26 February 2015 Photonic monitoring of chitosan nanostructured alginate microcapsules for drug release

Deepak Kumar Khajuria, Manish C. Konnur, Ramakrishna Vasireddi, D. Roy Mahapatra

Proceedings Volume 9303, Photonic Therapeutics and Diagnostics XI; 93033V (2015) https://doi.org/10.1117/12.2084966
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

By using a novel microfluidic set-up for drug screening applications, this study examines delivery of a novel risedronate based drug formulation for treatment of osteoporosis that was developed to overcome the usual shortcomings of risedronate, such as its low bioavailability and adverse gastric effects. Risedronate nanoparticles were prepared using muco-adhesive polymers such as chitosan as matrix for improving the intestinal cellular absorption of risedronate and also using a gastric-resistant polymer such as sodium alginate for reducing the gastric inflammation of risedronate. The in-vitro characteristics of the alginate encapsulated chitosan nanoparticles are investigated, including their stability, muco-adhesiveness, and Caco-2 cell permeability. Fluorescent markers are tagged with the polymers and their morphology within the microcapsules is imaged at various stages of drug release.

Citation Download Citation

Deepak Kumar Khajuria, Manish C. Konnur, Ramakrishna Vasireddi, and D. Roy Mahapatra "Photonic monitoring of chitosan nanostructured alginate microcapsules for drug release", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93033V (26 February 2015); https://doi.org/10.1117/12.2084966

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