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4 March 2015 Clinical trials in near infrared fluorescence imaging with IRDye 800CW
Daniel R. Draney
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Proceedings Volume 9311, Molecular-Guided Surgery: Molecules, Devices, and Applications; 93110L (2015) https://doi.org/10.1117/12.2079285
Event: SPIE BiOS, 2015, San Francisco, California, United States
Abstract
A monofunctional, heptamethine dye, IRDye® 800CW, is being manufactured under GMP conditions for use in human clinical trials. When attached to a suitable targeting agent and paired with an appropriate camera system, the dye allows Near Infrared (NIR) fluorescence imaging of tumor tissue during surgery. The talk will describe the properties of the dye and give an overview of current and planned clinical trials in Europe and the USA. The dye is available in both the NHS ester and carboxylate forms for conjugation to targeting molecules. A GMP toxicology study of the dye was described in a previous publication.
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Daniel R. Draney "Clinical trials in near infrared fluorescence imaging with IRDye 800CW", Proc. SPIE 9311, Molecular-Guided Surgery: Molecules, Devices, and Applications, 93110L (4 March 2015); https://doi.org/10.1117/12.2079285
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KEYWORDS
Near infrared
Surgery
Luminescence
Clinical trials
Tumors
In vivo imaging
Cancer
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