Optical mammography instrument for broadband spectral imaging with depth discrimination

Nishanth Krishnamurthy; Jana M. Kainerstorfer; Pamela G. Anderson; Angelo Sassaroli; Sergio Fantini

doi:10.1117/12.2077987

12 March 2015 Optical mammography instrument for broadband spectral imaging with depth discrimination

Nishanth Krishnamurthy, Jana M. Kainerstorfer, Pamela G. Anderson, Angelo Sassaroli, Sergio Fantini

Proceedings Volume 9319, Optical Tomography and Spectroscopy of Tissue XI; 93190J (2015) https://doi.org/10.1117/12.2077987
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We are developing a new instrument for diffuse optical mammography in parallel plate geometry that operates over a broad spectral range of 600-1000 nm, features a scan time of 1-2 min, and allows for dynamic measurements at a selected region of interest. Furthermore, this new instrument is capable of depth discrimination of optical inhomogeneities embedded in the examined tissue by using multiple off-axis detection fibers. Using a solid silicone phantoms, mimicking breast tissue with 39 mm thickness, we demonstrate the capability of this instrument to recover the depth of blood-vessel-like structures to within ~2 mm. Additionally, we demonstrate the capability of this instrument to perform dynamic optical measurements with a temporal sampling rate as high as 20 Hz. We describe our plans to integrate this rich spectral, spatial, and temporal information into a single instrument for translation into clinical measurements on breast cancer patients.

Citation Download Citation

Nishanth Krishnamurthy, Jana M. Kainerstorfer, Pamela G. Anderson, Angelo Sassaroli, and Sergio Fantini "Optical mammography instrument for broadband spectral imaging with depth discrimination", Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 93190J (12 March 2015); https://doi.org/10.1117/12.2077987

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