Towards next generation time-domain diffuse optics devices

Alberto Dalla Mora; Davide Contini; Simon R. Arridge; Fabrizio Martelli; Alberto Tosi; Gianluca Boso; Andrea Farina; Turgut Durduran; Edoardo Martinenghi; Alessandro Torricelli; Antonio Pifferi

doi:10.1117/12.2078955

5 March 2015 Towards next generation time-domain diffuse optics devices

Alberto Dalla Mora, Davide Contini, Simon R. Arridge, Fabrizio Martelli, Alberto Tosi, Gianluca Boso, Andrea Farina, Turgut Durduran, Edoardo Martinenghi, Alessandro Torricelli, Antonio Pifferi

Author Affiliations +

Proceedings Volume 9319, Optical Tomography and Spectroscopy of Tissue XI; 93191J (2015) https://doi.org/10.1117/12.2078955
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Diffuse Optics is growing in terms of applications ranging from e.g. oximetry, to mammography, molecular imaging, quality assessment of food and pharmaceuticals, wood optics, physics of random media. Time-domain (TD) approaches, although appealing in terms of quantitation and depth sensibility, are presently limited to large fiber-based systems, with limited number of source-detector pairs. We present a miniaturized TD source-detector probe embedding integrated laser sources and single-photon detectors. Some electronics are still external (e.g. power supply, pulse generators, timing electronics), yet full integration on-board using already proven technologies is feasible. The novel devices were successfully validated on heterogeneous phantoms showing performances comparable to large state-of-the-art TD rack-based systems. With an investigation based on simulations we provide numerical evidence that the possibility to stack many TD compact source-detector pairs in a dense, null source-detector distance arrangement could yield on the brain cortex about 1 decade higher contrast as compared to a continuous wave (CW) approach. Further, a 3-fold increase in the maximum depth (down to 6 cm) is estimated, opening accessibility to new organs such as the lung or the heart. Finally, these new technologies show the way towards compact and wearable TD probes with orders of magnitude reduction in size and cost, for a widespread use of TD devices in real life.

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Alberto Dalla Mora, Davide Contini, Simon R. Arridge, Fabrizio Martelli, Alberto Tosi, Gianluca Boso, Andrea Farina, Turgut Durduran, Edoardo Martinenghi, Alessandro Torricelli, and Antonio Pifferi "Towards next generation time-domain diffuse optics devices", Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 93191J (5 March 2015); https://doi.org/10.1117/12.2078955

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