Dual modality of non-contact photoacoustic tomography and fluorescence imaging using double cladding fiber

Jonghyun Eom; Seong Jun Park; Ju Wan Kim; Soongho Park; Byeong Ha Lee

doi:10.1117/12.2077341

11 March 2015 Dual modality of non-contact photoacoustic tomography and fluorescence imaging using double cladding fiber

Jonghyun Eom, Seong Jun Park, Ju Wan Kim, Soongho Park, Byeong Ha Lee

Author Affiliations +

Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 93233W (2015) https://doi.org/10.1117/12.2077341
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We present a fiber-based dual-modal imaging system that combines non-contact photoacoustic tomography (NCPAT) and fluorescence imaging by using double cladding fiber (DCF). The NCPAT system utilizing an all-fiber heterodyne interferometer as an ultrasound detector measures the photoacoustic signal at the sample surface without physical contact. Fluorescence imaging system is composed of fiber-optics to deliver the excitation light and the emission light. For combined system the probe consists of a specially fabricated DCF coupler and a lensed fiber so that we can simultaneously acquire the signals of two systems with the same probe. The DCF has a core and two claddings, inner and outer, which allows two concentric light-guiding channels via the core and the inner cladding. The lensed fiber of the DCF probe is compactly fabricated to focus the interferometer light and the excitation light, and to efficiently collect the fluorescence signal. To demonstrate the feasibility of the proposed dual-modal system, we have conducted phantom experiments using tissue mimicking phantoms which contained a couple of tubes filled with fluorescein solution and black ink, respectively. The proposed imaging system is implanted with fiber-optic configurations so that it has the potential for minimally invasive and improved diagnosis and guided treatment of diseases.

Citation Download Citation

Jonghyun Eom, Seong Jun Park, Ju Wan Kim, Soongho Park, and Byeong Ha Lee "Dual modality of non-contact photoacoustic tomography and fluorescence imaging using double cladding fiber", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93233W (11 March 2015); https://doi.org/10.1117/12.2077341

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KEYWORDS

Luminescence

Imaging systems

Photoacoustic spectroscopy

Cladding

Ultrasonography

Photoacoustic tomography

Bragg cells

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