Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model

Joseph T. Acquaviva III; Aamr M. Hasanjee; Cody F. Bahavar; Fefian Zhou; Hong Liu; Eric W. Howard; Liz C. Bullen; Ricardo P. Silvy; Wei R. Chen

doi:10.1117/12.2080890

9 March 2015 Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model

Joseph T. Acquaviva III, Aamr M. Hasanjee, Cody F. Bahavar, Fefian Zhou, Hong Liu, Eric W. Howard, Liz C. Bullen, Ricardo P. Silvy, Wei R. Chen

Author Affiliations +

Proceedings Volume 9324, Biophotonics and Immune Responses X; 932415 (2015) https://doi.org/10.1117/12.2080890
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Laser immunotherapy (LIT) is being developed as a treatment modality for metastatic cancer which can destroy primary tumors and induce effective systemic anti-tumor responses by using a targeted treatment approach in conjunction with the use of a novel immunoadjuvant, glycated chitosan (GC). In this study, Non-invasive Laser Immunotherapy (NLIT) was used as the primary treatment mode. We incorporated single-walled carbon nanotubes (SWNTs) into the treatment regimen to boost the tumor-killing effect of LIT. SWNTs and GC were conjugated to create a completely novel, immunologically modified carbon nanotube (SWNT-GC). To determine the efficacy of different laser irradiation durations, 5 minutes or 10 minutes, a series of experiments were performed. Rats were inoculated with DMBA-4 cancer cells, a highly aggressive metastatic cancer cell line. Half of the treatment group of rats receiving laser irradiation for 10 minutes survived without primary or metastatic tumors. The treatment group of rats receiving laser irradiation for 5 minutes had no survivors. Thus, Laser+SWNT-GC treatment with 10 minutes of laser irradiation proved to be effective at reducing tumor size and inducing long-term anti-tumor immunity.

Citation Download Citation

Joseph T. Acquaviva III, Aamr M. Hasanjee, Cody F. Bahavar, Fefian Zhou, Hong Liu, Eric W. Howard, Liz C. Bullen, Ricardo P. Silvy, and Wei R. Chen "Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model", Proc. SPIE 9324, Biophotonics and Immune Responses X, 932415 (9 March 2015); https://doi.org/10.1117/12.2080890

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available