Multifunctional perfluorocarbon nanoemulsions for cancer therapy and imaging

Donald A. Fernandes; Dennis D. Fernandes; Yan J. Wang; Yuchong Li; Claudiu C. Gradinaru; Dérick Rousseau; Michael C. Kolios

doi:10.1117/12.2079914

19 March 2015 Multifunctional perfluorocarbon nanoemulsions for cancer therapy and imaging

Donald A. Fernandes, Dennis D. Fernandes, Yan J. Wang, Yuchong Li, Claudiu C. Gradinaru, Dérick Rousseau, Michael C. Kolios

Author Affiliations +

Proceedings Volume 9338, Colloidal Nanoparticles for Biomedical Applications X; 93380R (2015) https://doi.org/10.1117/12.2079914
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

There is currently interest in the development of nanoemulsions as imaging and therapeutic agents, particularly perfluorohexane (PFH) droplets, whose amphiphilic shell protects drugs against physico-chemical and enzymatic degradation. When delivered to their target sites, these perfluorocarbon (PFC) droplets can vaporize upon laser excitation, efficiently releasing their drug payload and/or imaging tracers. Due to the optical properties of gold, coupling PFC droplets with gold nanoparticles significantly reduces the energy required for vaporization. In this work, nanoemulsions with a PFC core and Zonyl FSP surfactant shell were produced using sonication. Droplets were characterized in terms of size and morphology using high resolution fluorescence microscopy (i.e. total internal reflection fluorescence microscopy, TIRFM), fluorescence correlation spectroscopy (FCS), transmission electron microscopy (TEM), and light scattering techniques (i.e. dynamic light scattering, DLS). The ability of PFC droplets to vaporize was demonstrated using optical light microscopy.

Citation Download Citation

Donald A. Fernandes, Dennis D. Fernandes, Yan J. Wang, Yuchong Li, Claudiu C. Gradinaru, Dérick Rousseau, and Michael C. Kolios "Multifunctional perfluorocarbon nanoemulsions for cancer therapy and imaging", Proc. SPIE 9338, Colloidal Nanoparticles for Biomedical Applications X, 93380R (19 March 2015); https://doi.org/10.1117/12.2079914

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