Quantification, validation, and follow-up of small bowel motility in Crohn's disease

Juan J. Cerrolaza; Jennifer Q. Peng; Nabile M. Safdar M.D.; Laurie Conklin; Raymond Sze; Marius George Linguraru

doi:10.1117/12.2081480

20 March 2015 Quantification, validation, and follow-up of small bowel motility in Crohn's disease

Juan J. Cerrolaza, Jennifer Q. Peng, Nabile M. Safdar M.D., Laurie Conklin, Raymond Sze, Marius George Linguraru

Proceedings Volume 9414, Medical Imaging 2015: Computer-Aided Diagnosis; 94141D (2015) https://doi.org/10.1117/12.2081480
Event: SPIE Medical Imaging, 2015, Orlando, Florida, United States

Abstract

The use of magnetic resonance enterography (MRE) has become a mainstay in the evaluation, assessment and follow up of inflammatory bowel diseases, such as Crohn’s disease (CD), thanks to its high image quality and its non-ionizing nature. In particular, the advent of faster MRE sequences less sensitive to image-motion artifacts offers the possibility to obtain visual, structural and functional information of the patient’s small bowel. However, the inherent subjectivity of the mere visual inspection of these images often hinders the accurate identification and monitoring of the pathological areas. In this paper, we present a framework that provides quantitative and objective motility information of the small bowel from free-breathing MRE dynamic sequences. After compensating for the breathing motion of the patient, we create personalized peristaltic activity maps via optical flow analysis. The result is the creation of a new set of images providing objective and precise functional information of the small bowel. The accuracy of the new method was also evaluated from two different perspectives: objective accuracy (1.1 ± 0.6 mm/s of error), i.e., the ability of the system to provide quantitative and accurate information about the motility of moving bowel landmarks, and subjective accuracy (avg. difference of 0.7 ± 0.7 in a range of 1 to 5), i.e., the degree of agreement with the subjective evaluation of an expert. Finally, the practical utility of the new method was successfully evaluated in a preliminary study with 32 studies of healthy and CD cases, showing its potential for the fast and accurate assessment and follow up of CD in the small bowel.

Citation Download Citation

Juan J. Cerrolaza, Jennifer Q. Peng, Nabile M. Safdar M.D., Laurie Conklin, Raymond Sze, and Marius George Linguraru "Quantification, validation, and follow-up of small bowel motility in Crohn's disease", Proc. SPIE 9414, Medical Imaging 2015: Computer-Aided Diagnosis, 94141D (20 March 2015); https://doi.org/10.1117/12.2081480

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Optical flow

Image segmentation

Image registration

Imaging systems

Magnetic resonance imaging

Abdomen

Magnetism

Show All Keywords

Keywords/Phrases

Search In:

Publication Years