Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiation

Alessandro D. Mota; André M. Cestari; André O. de Oliveira; Anselmo G. Oliveira; Cristina H. B. Terruggi; Giuliano Rossi; Jarbas C. Castro; João P. B. Ligabô; Tiago A. Ortega; Tiago Rosa

doi:10.1117/12.2187265

8 September 2015 Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiation

Alessandro D. Mota, André M. Cestari, André O. de Oliveira, Anselmo G. Oliveira, Cristina H. B. Terruggi, Giuliano Rossi, Jarbas C. Castro , João P. B. Ligabô, Tiago A. Ortega, Tiago Rosa

Author Affiliations +

Proceedings Volume 9571, Fourteenth International Conference on Solid State Lighting and LED-based Illumination Systems; 95710X (2015) https://doi.org/10.1117/12.2187265
Event: SPIE Optical Engineering + Applications, 2015, San Diego, California, United States

Abstract

This work presents an innovative cross-linking procedure to keratoconus treatment, a corneal disease. It includes the development of an ultraviolet controlled emission portable device based on LED source and a new formulation of a photosensitive drug called riboflavin. Thus new formulation improves drug administration by its transepithelial property. The UV reaction with riboflavin in corneal tissue leads to a modification of corneal collagen fibers, turning them more rigid and dense, and consequently restraining the advance of the disease. We present the control procedures to maintain UV output power stable up to 45mw/cm², the optical architecture that leads to a homogeneous UV spot and the new formulation of Riboflavin.

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Alessandro D. Mota, André M. Cestari, André O. de Oliveira, Anselmo G. Oliveira, Cristina H. B. Terruggi, Giuliano Rossi, Jarbas C. Castro , João P. B. Ligabô, Tiago A. Ortega, and Tiago Rosa "Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiation", Proc. SPIE 9571, Fourteenth International Conference on Solid State Lighting and LED-based Illumination Systems, 95710X (8 September 2015); https://doi.org/10.1117/12.2187265

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