A feasibility study of singlet oxygen explicit dosmietry (SOED) of PDT by intercomparison with a singlet oxygen luminescence dosimetry (SOLD) system

Michele M. Kim; Rozhin Penjweini; Nathan R. Gemmell; Israel Veilleux; Aongus McCarthy; Gerald Buller; Robert H. Hadfield; Brian C. Wilson; Timothy C. Zhu

doi:10.1117/12.2213236

1 March 2016 A feasibility study of singlet oxygen explicit dosmietry (SOED) of PDT by intercomparison with a singlet oxygen luminescence dosimetry (SOLD) system

Michele M. Kim, Rozhin Penjweini, Nathan R. Gemmell, Israel Veilleux, Aongus McCarthy, Gerald Buller, Robert H. Hadfield, Brian C. Wilson, Timothy C. Zhu

Author Affiliations +

Proceedings Volume 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV; 969406 (2016) https://doi.org/10.1117/12.2213236
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

An explicit dosimetry model has been developed to calculate the apparent reacted ¹O₂ concentration ([¹O₂]_rx) in an in-vivo model. In the model, a macroscopic quantity, g, is introduced to account for oxygen perfusion to the medium during PDT. In this study, the SOED model is extended for PDT treatment in phantom conditions where vasculature is not present; the oxygen perfusion is achieved through the air-phantom interface instead. The solution of the SOED model is obtained by solving the coupled photochemical rate equations incorporating oxygen perfusion through the air-liquid interface. Experiments were performed for two photosensitizers (PS), Rose Bengal (RB) and Photofrin, in solution, using SOED and SOLD measurements to determine both the instantaneous [¹O₂] as well as cumulative [¹O₂]_rx concentrations, where [¹O₂=(1/τ_▵)•∫[¹O₂]dt. The PS concentrations varied between 10 and 100 mM for RB and ~200 mM for Photofrin. The resulting magnitudes of [¹O₂] were compared between SOED and SOLD.

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Michele M. Kim, Rozhin Penjweini, Nathan R. Gemmell, Israel Veilleux, Aongus McCarthy, Gerald Buller, Robert H. Hadfield, Brian C. Wilson, and Timothy C. Zhu "A feasibility study of singlet oxygen explicit dosmietry (SOED) of PDT by intercomparison with a singlet oxygen luminescence dosimetry (SOLD) system", Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 969406 (1 March 2016); https://doi.org/10.1117/12.2213236

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