Single shot line-field optical coherence elastography

Chih-Hao Liu; Alexander Schill; Manmohan Singh; Chen Wu; Jiasong Li; Zhaolong Han; Raksha Raghunathan; Tina Kazemi; Achuth Nair; Thomas Hsu; Kirill V. Larin

doi:10.1117/12.2213413

8 March 2016 Single shot line-field optical coherence elastography

Chih-Hao Liu, Alexander Schill, Manmohan Singh, Chen Wu, Jiasong Li, Zhaolong Han, Raksha Raghunathan, Tina Kazemi, Achuth Nair, Thomas Hsu, Kirill V. Larin

Author Affiliations +

Proceedings Volume 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX; 96971R (2016) https://doi.org/10.1117/12.2213413
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Elastic wave imaging optical coherence elastography (EWI-OCE) is an emerging technique that can quantify local biomechanical properties of tissues. However, long acquisition times make this technique unfeasible for clinical use. Here, we demonstrate a noncontact single shot line-field OCE technique using a line-field interferometer and an air-pulse delivery system. The spatial-temporal elastic wave propagation profile was acquired in a single shot and used to quantify the elastic wave group velocity in tissue. Results on tissue-mimicking phantoms and chicken breast muscle agreed well with mechanical compression testing, demonstrating that the presented method can effectively reduce the OCE acquisition time to a few milliseconds in biological application.

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Chih-Hao Liu, Alexander Schill, Manmohan Singh, Chen Wu, Jiasong Li, Zhaolong Han, Raksha Raghunathan, Tina Kazemi, Achuth Nair, Thomas Hsu, and Kirill V. Larin "Single shot line-field optical coherence elastography", Proc. SPIE 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, 96971R (8 March 2016); https://doi.org/10.1117/12.2213413

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