Articulated dual modality photoacoustic and optical coherence tomography probe for preclinical and clinical imaging
(Conference Presentation)

Mengyang Liu; Behrooz Zabihian; Jessika Weingast M.D.; Boris Hermann; Zhe Chen; Edward Z. Zhang; Paul C. Beard; Hubert Pehamberger M.D.; Wolfgang Drexler

doi:10.1117/12.2212577

27 April 2016 Articulated dual modality photoacoustic and optical coherence tomography probe for preclinical and clinical imaging (Conference Presentation)

Mengyang Liu, Behrooz Zabihian, Jessika Weingast M.D., Boris Hermann, Zhe Chen, Edward Z. Zhang, Paul C. Beard, Hubert Pehamberger M.D., Wolfgang Drexler

Author Affiliations +

Proceedings Volume 9708, Photons Plus Ultrasound: Imaging and Sensing 2016; 970817 (2016) https://doi.org/10.1117/12.2212577
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

The combination of photoacoustic tomography (PAT) with optical coherence tomography (OCT) has seen steady progress over the past few years. With the benchtop and semi-benchtop configurations, preclinical and clinical results have been demonstrated, paving the way for wider applications using dual modality PAT/OCT systems. However, as for the most updated semi-benchtop PAT/OCT system which employs a Fabry-Perot polymer film sensor, it is restricted to only human palm imaging due to the limited flexibility of the probe. The passband limit of the polymer film sensor further restricts the OCT source selection and reduces the sensitivity of the combined OCT system. To tackle these issues, we developed an articulated PAT/OCT probe for both preclinical and clinical applications. In the probe design, the sample arm of OCT sub-system and the interrogation part of the PAT sub-system are integrated into one compact unit. The polymer film sensor has a quick release function so that before each OCT scan, the sensor can be taken off to avoid the sensitivity drop and artefacts in OCT. The holding mechanism of the sensor is also more compact compared to previous designs, permitting access to uneven surfaces of the subjects. With the help of the articulated probe and a patient chair, we are able to perform co-registered imaging on human subjects on both upper and lower extremities while they are at rest positions. An increase in performance characteristics is also achieved. Patients with skin diseases are currently being recruited to test its clinical feasibility.

Conference Presentation

Citation Download Citation

Mengyang Liu, Behrooz Zabihian, Jessika Weingast M.D., Boris Hermann, Zhe Chen, Edward Z. Zhang, Paul C. Beard, Hubert Pehamberger M.D., and Wolfgang Drexler "Articulated dual modality photoacoustic and optical coherence tomography probe for preclinical and clinical imaging (Conference Presentation)", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 970817 (27 April 2016); https://doi.org/10.1117/12.2212577

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Optical coherence tomography

Sensors

Polymer thin films

Polymeric sensors

Polymers

Acquisition tracking and pointing

Imaging systems

Show All Keywords

Keywords/Phrases

Search In:

Publication Years