7 March 2022Development and characterization of a disposable sub-millimeter fiberoptic Raman needle probe for real-time deep tissue and biofluids Raman measurements
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We develop a disposable sub-millimeter fiberoptic Raman needle probe for real-time in vivo tissue and biofluids Raman measurements. High-quality tissue Raman spectra in fingerprint and high-wavenumber regions can be collected within sub-second from different tissue types and biofluids using the needle Raman probe fabricated together with the structured background subtraction algorithm developed. We further validate the depth-resolved deep tissue Raman spectra measurement capability of the fiberoptic needle Raman probe by advancing the needle Raman probe into a mice brain model. We demonstrate that the sub-millimeter fiberoptic Raman probe developed can achieve real-time time collection of deep tissue and biofluids FP/HW Raman spectra with high signal to noise ratios, suggesting the potential of dual functioning of Raman optical biopsy and fine-needle aspiration biopsy for in vivo deep tissue and biofluids characterization in the human body.
Chi Shu,Wei Zheng,Zhuo Wang,Changyuan Yu, andZhiwei Huang
"Development and characterization of a disposable sub-millimeter fiberoptic Raman needle probe for real-time deep tissue and biofluids Raman measurements", Proc. SPIE PC11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, PC119570F (7 March 2022); https://doi.org/10.1117/12.2614404
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Chi Shu, Wei Zheng, Zhuo Wang, Changyuan Yu, Zhiwei Huang, "Development and characterization of a disposable sub-millimeter fiberoptic Raman needle probe for real-time deep tissue and biofluids Raman measurements," Proc. SPIE PC11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, PC119570F (7 March 2022); https://doi.org/10.1117/12.2614404