Brendon S. Restallhttps://orcid.org/0000-0001-6410-7657,1 Brendyn D. Cikaluk,1 Nathaniel J. M. Haven,1 Matthew T. Martell,1 Sveta Silverman,1 Lashan Peiris,1 Jean Deschenes,1 Roger J. Zemp1
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Previous photoacoustic remote sensing virtual histology approaches were too slow to use intraoperatively. We present a new scanning methodology with simultaneous galvanometer mirror and constant velocity mechanical scanning to greatly increase image acquisition speed. Human breast and prostate samples are imaged over an area of 4mm x 4mm in 40s with a 0.5μm resolution resolving both cancerous and healthy tissue. Histological detail is clearly visible in our images where tissue organization and subcellular nuclei density can be observed to aid histologists in determining margin status and cancer grading.
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Brendon S. Restall, Brendyn D. Cikaluk, Nathaniel J. M. Haven, Matthew T. Martell, Sveta Silverman, Lashan Peiris, Jean Deschenes, Roger J. Zemp, "Rapid virtual H&E photoacoustic remote sensing using constant velocity and galvanometer mirror scanning," Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC1196024 (7 March 2022); https://doi.org/10.1117/12.2610322