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3 March 2022 Generalized targeting and photothermal treatment of infectious agents with biodegradable plasmonic nanocrystals
Joshua Kays, Allison Dennis
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Proceedings Volume PC11977, Colloidal Nanoparticles for Biomedical Applications XVII; PC1197707 (2022) https://doi.org/10.1117/12.2610100
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Antibiotic-resistant infections (ARIs) are a growing public health threat, and nanomaterial-based medicines present a solution due to their unique method of action that is unlikely to develop an evolutionary defense. We synthesize biodegradable, non-toxic bornite nanocrystals (NCs) that possess an LSPR peak at 1100nm. We coat these NCs with a generalized targeting peptide and demonstrate their lethality to multiple bacteria species. Finally, we show that these particles degrade in vitro and are non-toxic to mammalian cells at a high concentrations, showing the potential of these NCs as antibacterial agents.
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Joshua Kays and Allison Dennis "Generalized targeting and photothermal treatment of infectious agents with biodegradable plasmonic nanocrystals", Proc. SPIE PC11977, Colloidal Nanoparticles for Biomedical Applications XVII, PC1197707 (3 March 2022); https://doi.org/10.1117/12.2610100
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KEYWORDS
Nanocrystals
Plasmonics
Bacteria
Light emitting diodes
Nanomaterials
Particles
Photothermal effect
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