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17 March 2023 Combined optogenetic and electrical stimulation of mouse retinal ganglion cells improves stimulation efficacy
James M. Begeng, William Kwan, Emma Brunton, Tatiana Kameneva, Paul R. Stoddart, Michael R. Ibbotson, Wei Tong, Rachael T. Richardson
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Proceedings Volume PC12366, Optogenetics and Optical Manipulation 2023; PC123660B (2023) https://doi.org/10.1117/12.2657410
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Conventional electrically-stimulating retinal prostheses exhibit low stimulus resolution due to current spread, which precludes high-acuity vision. Optogenetic neuromodulation techniques offer a high stimulus resolution, and are uniquely well-suited to exploit the optical accessibility of the retina. However, such techniques often exhibit a low stimulus response rate, and may risk phototoxic damage during chronic applications. The present study uses combined optogenetic and electrical co-stimulation to reduce the current threshold requirements, thereby limiting current spread. A time delay in the electrical stimulus was found to improve stimulation efficacy, and response probability was increased during co-stimulation at higher pulse train frequencies.
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James M. Begeng, William Kwan, Emma Brunton, Tatiana Kameneva, Paul R. Stoddart, Michael R. Ibbotson, Wei Tong, and Rachael T. Richardson "Combined optogenetic and electrical stimulation of mouse retinal ganglion cells improves stimulation efficacy", Proc. SPIE PC12366, Optogenetics and Optical Manipulation 2023, PC123660B (17 March 2023); https://doi.org/10.1117/12.2657410
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KEYWORDS
Optogenetics
Action potentials
Neurons
Retina
Electrodes
Ion channels
Spatial resolution
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