The brain is the most complex organ in the human body, and brain diseases are highly challenging to diagnose, monitor, and treat. Nanomaterials have emerged as a unique wireless interface with the brain in the micro/nanoscale. I will discuss our recent efforts to develop new tools using advanced nanomaterials and photonics to further understand and access the brain. These include exciting capabilities to remotely control protein activity, study neurochemical modulation, and change the blood-brain barrier permeability. These new tools provide insights into the brain microenvironment and a unique opportunity to develop strategies to treat brain diseases.
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