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15 March 2023 Quantitative micro-elastography for biomechanical evaluation of chronic liver injury in mouse models (Conference Presentation)
Alireza Mowla, Brendan Kennedy, George Yeoh, Rose Belford, Nina Tirnitz-Parker, Julia Koehn, Nathan Main
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Proceedings Volume PC12381, Optical Elastography and Tissue Biomechanics X; PC123810B (2023) https://doi.org/10.1117/12.2647333
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Hepatocellular carcinoma is the most common type of primary liver cancer, which mainly develops from cirrhosis. Although it is known that cirrhosis increases the elasticity of liver, the possible role of increased microenvironment elasticity in deriving hepatocellular carcinoma is not understood, due to the paucity of micro-scale elastography techniques. We propose quantitative micro-elastography for the mechanical assessment of liver micro-structures during chronic injury in mouse models. Our results show a significant increase in the mean elasticity and elasticity heterogeneity caused by advanced chronic liver injury, and a microscale correlation between the elasticity variation and common pathological features such as fibrosis.
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Alireza Mowla, Brendan Kennedy, George Yeoh, Rose Belford, Nina Tirnitz-Parker, Julia Koehn, and Nathan Main "Quantitative micro-elastography for biomechanical evaluation of chronic liver injury in mouse models (Conference Presentation)", Proc. SPIE PC12381, Optical Elastography and Tissue Biomechanics X, PC123810B (15 March 2023); https://doi.org/10.1117/12.2647333
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KEYWORDS
Liver
Injuries
Mouse models
Collagen
Elastography
Liver cancer
Optical coherence tomography
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