VGT-309:  A tumor-targeted near-infrared imaging agent for intraoperative cancer detection

Eric Bensen

doi:10.1117/12.3022626

13 March 2024 VGT-309: A tumor-targeted near-infrared imaging agent for intraoperative cancer detection

Eric Bensen

Proceedings Volume PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X; PC128250D (2024) https://doi.org/10.1117/12.3022626
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Curative cancer surgery depends on complete removal of malignant tissue. However, intraoperative differentiation of cancer from healthy tissue remains a surgical challenge. This is especially true for minimally invasive procedures where tactile and visual cues are reduced. Intraoperative molecular imaging (IMI) has emerged as a promising solution to these challenges by delivering real-time visual feedback to the surgeon, increasing the likelihood of complete tumor resection while reducing the unnecessary removal of healthy tissue. VGT-309 is an activatable IMI agent that targets cysteine cathepsins, a family of proteases enriched in a broad range of solid tumors. The mechanism of action, preclinical work, and clinical status of VGT-309 in ongoing and completed clinical trials for cancer in the lung will be presented.

Conference Presentation

Citation Download Citation

Eric Bensen "VGT-309: A tumor-targeted near-infrared imaging agent for intraoperative cancer detection", Proc. SPIE PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X, PC128250D (13 March 2024); https://doi.org/10.1117/12.3022626

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