Intrinsic signal optoretinography of photoreceptor hyperexcitability associated with Alzheimer’s disease in the 3xTg-AD mice

Guangying Ma; Tae-Hoon Kim; Taeyoon Son; Jie Ding; Shaiban Ahmed; Tobiloba Adejumo; Xincheng Yao

doi:10.1117/12.3001037

13 March 2024 Intrinsic signal optoretinography of photoreceptor hyperexcitability associated with Alzheimer’s disease in the 3xTg-AD mice

Guangying Ma, Tae-Hoon Kim, Taeyoon Son, Jie Ding, Shaiban Ahmed, Tobiloba Adejumo, Xincheng Yao

Author Affiliations +

Proceedings Volume PC12828, Neural Imaging and Sensing 2024; PC128280V (2024) https://doi.org/10.1117/12.3001037
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Early detection of Alzheimer's disease (AD) is crucial for prompt interventions to preserve brain function. Neuronal hyperexcitability promises a biomarker of early-stage AD. However, in vivo, detection of neuronal hyperexcitability is technically challenging. With a custom-designed optical coherence tomography (OCT), this study demonstrated the feasibility of using retinal intrinsic optical signal (IOS) imaging, also known as optoretinography (ORG), for detecting photoreceptor hyperexcitability associated with early-stage AD. Morphological OCT analysis revealed detectable thinning of retinal thickness in 3xTg-AD mice from 5 months of age. In contrast, functional ORG disclosed increased photoreceptor hyperexcitability of 3xTg-AD mice from 4 months of age.

Citation Download Citation

Guangying Ma, Tae-Hoon Kim, Taeyoon Son, Jie Ding, Shaiban Ahmed, Tobiloba Adejumo, and Xincheng Yao "Intrinsic signal optoretinography of photoreceptor hyperexcitability associated with Alzheimer’s disease in the 3xTg-AD mice", Proc. SPIE PC12828, Neural Imaging and Sensing 2024, PC128280V (13 March 2024); https://doi.org/10.1117/12.3001037

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available