The emergence of super-resolution photothermal infrared spectroscopy

Craig Prater

doi:10.1117/12.3023795

13 March 2024 The emergence of super-resolution photothermal infrared spectroscopy

Craig Prater

Proceedings Volume PC12836, Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis; PC128360L (2024) https://doi.org/10.1117/12.3023795
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Optical Photothermal Infrared (O-PTIR) is a rapidly emerging technique for super-resolution infrared spectroscopy that uses a short wavelength visible probe beam to detect infrared absorption by a sample with 10-30X better spatial resolution than conventional infrared spectroscopy. O-PTIR has been used in biomedical applications including cancer, neurodegenerative disease, cellular metabolism research, and other areas. O-PTIR has recently been combined fluorescence imaging to provide targeted IR spectroscopic analysis of fluorescently labeled regions of cells and tissue and also to rapidly detect IR absorption over a wide sample area. This presentation will overview O-PTIR technology and survey a variety of applications.

Conference Presentation

Citation Download Citation

Craig Prater "The emergence of super-resolution photothermal infrared spectroscopy", Proc. SPIE PC12836, Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis, PC128360L (13 March 2024); https://doi.org/10.1117/12.3023795

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