Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition

Zhenping Xu; Feifan Zhou; Miao Wang

doi:10.1117/12.3004978

13 March 2024 Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition

Zhenping Xu, Feifan Zhou, Miao Wang

Author Affiliations +

Proceedings Volume PC12843, Biophotonics and Immune Responses XIX; PC128430S (2024) https://doi.org/10.1117/12.3004978
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Meningeal lymphatic vessels (mLVs) have been confirmed to scavenge amyloid beta (Aβ) from brain and might been damaged early on by deleterious processes implicated in AD, which is considered as a novel target for Alzheimer’s disease (AD) treatment. However, whether modulation of mLVs in the early stage could delay pathological progression of AD remains unknown. In this study, based on the superficial distribution of mLVs in dura, a near-infrared light was utilized to modulate lymphatic drainage of 3-month AD mice, and the therapeutic effect and potential mechanism were investigated on the mice at 6 months of age. The results showed that light ameliorates cognitive deficits and AD-associated pathology of 6-month-old AD mice by preserving transport ability of mLVs since the early stage. This study provides a novel strategy for AD prevention and intervention via mLVs modulation in early time.

Conference Presentation

Citation Download Citation

Zhenping Xu, Feifan Zhou, and Miao Wang "Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition", Proc. SPIE PC12843, Biophotonics and Immune Responses XIX, PC128430S (13 March 2024); https://doi.org/10.1117/12.3004978

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