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We demonstrate here the facile synthesis of seed-mediated surfactant-free nanostars over a range of controlled spike lengths from 50 to 110 nm diameter and spike sharpness from 2 to 10 nm with a controlled morphology which can be achieved by changing the concentration of the chemicals required in this synthesis. To investigate the potential SERS sensing applications for point-of-care detection and real-time monitoring, we have utilized our gold nanostars for bacterial pathogens, and chronic disease biomarkers detection. Compared to other nanoparticle-based sensing applications, our optimized GNS promises to become a much more versatile and tunable SERS sensor.
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