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13 March 2024 ZnSe/InP/ZnS core-shell-shell quantum dots enable paired agent imaging in NIR-I window
Amish Patel, Allison M. Dennis
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Proceedings Volume PC12859, Colloidal Nanoparticles for Biomedical Applications XIX; PC1285905 (2024) https://doi.org/10.1117/12.3001869
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Inverted InP quantum dots emitting in the NIR-I window (700-900 nm) are promising fluorescent contrast agents for paired-agent imaging (PAI) due to their amenability to size-matching without compromising photoluminescence quantum yield. We present an optimized synthesis that uses drip addition of InP magic sized clusters (MSCs) as single source precursors. This method eliminates pyrophoric precursor from the shelling reaction and significantly reduces reaction time. We then synthesized a size-matched pair of NIR-I emitting inverted InP QDs for two-color PAI and then demonstrated two color NIR-I imaging of this QD pair in liquid phantoms and tumor spheroid models in vitro.
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Amish Patel and Allison M. Dennis "ZnSe/InP/ZnS core-shell-shell quantum dots enable paired agent imaging in NIR-I window", Proc. SPIE PC12859, Colloidal Nanoparticles for Biomedical Applications XIX, PC1285905 (13 March 2024); https://doi.org/10.1117/12.3001869
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KEYWORDS
Quantum dots
Windows
Quantum imaging
Contrast agents
In vitro testing
Zinc selenide
Solubility
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