Developing near-infrared emissive DNA-stabilized silver nanoclusters for biomedical imaging in the tissue transparency window

Stacy M. Copp

doi:10.1117/12.3003329

13 March 2024 Developing near-infrared emissive DNA-stabilized silver nanoclusters for biomedical imaging in the tissue transparency window

Stacy M. Copp

Author Affiliations +

Proceedings Volume PC12859, Colloidal Nanoparticles for Biomedical Applications XIX; PC1285907 (2024) https://doi.org/10.1117/12.3003329
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The increased transparency of biological tissues and fluids to near-infrared (NIR) light motivates the development of NIR fluorescence imaging. We are developing a promising new class of NIR emitters for fluorescence imaging, DNA-stabilized silver nanoclusters (Ag-DNAs), for bioimaging and sensing. By developing chemically-informed machine learning models, we map the sequence of the templating DNA oligomer onto silver nanocluster color, allowing us to discover new NIR-emissive Ag-DNAs. We also determine how nanocluster geometry influences photophysical and chiroptical properties. Finally, we report that Ag-DNAs can retain their chemical stability in biologically relevant solutions when protected by additional halide ligands. Together, this work has led to the development of new NIR-emissive Ag-DNAs for potential applications as fluorescent contrast agents in the NIR tissue transparency window.

Conference Presentation

Citation Download Citation

Stacy M. Copp "Developing near-infrared emissive DNA-stabilized silver nanoclusters for biomedical imaging in the tissue transparency window", Proc. SPIE PC12859, Colloidal Nanoparticles for Biomedical Applications XIX, PC1285907 (13 March 2024); https://doi.org/10.1117/12.3003329

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