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13 March 2024 Biodistribution of rare-earth nanocrystals revealed by NIR-II Imaging
Lingdong Sun
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Proceedings Volume PC12859, Colloidal Nanoparticles for Biomedical Applications XIX; PC128590A (2024) https://doi.org/10.1117/12.3003814
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
The biodistribution of nanoparticles becomes a critical concern for further clinical translation. Recent studies have demonstrated that, in addition to the liver and spleen, bone also plays a crucial role in nanoparticle distribution following systemic administration. However, the factors influencing the accumulation of nanoparticles in skeletal tissues remain unclear. We conducted an investigation into the distribution and retention of rare-earth nanocrystals with varying sizes and surface modifications using in vivo near-infrared IIb imaging. The findings revealed that within a few minutes after intravenous injection, the rare earth nanocrystals were swiftly concentrated in the bone marrow through the vascular system. Furthermore, there was a more pronounced accumulation observed for nanocrystals possessing carboxyl groups and smaller dimensions. Notably, the PEG-modified nanocrystals exhibit enhanced stability and biocompatibility, rendering them an ideal candidate for bone marrow imaging. This study lays a foundation for the development of nanoagents targeting bone-related diseases and elucidates some of the mechanisms underlying nanoparticles retention in the bone marrow.
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Lingdong Sun "Biodistribution of rare-earth nanocrystals revealed by NIR-II Imaging", Proc. SPIE PC12859, Colloidal Nanoparticles for Biomedical Applications XIX, PC128590A (13 March 2024); https://doi.org/10.1117/12.3003814
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KEYWORDS
Nanocrystals
Nanoparticles
Bone
Biological imaging
Photons
Spleen
Tissues
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