Development and validation of a multiwavelength spatial domain near-infrared oximeter to detect cerebral hypoxia-ischemia

Lindsey A. Nelson; John C. McCann; Andreas W. Loepke; Jun Wu; Baruch Ben-Dor; Dean C. Kurth M.D.

doi:10.1117/1.2393251

1 November 2006 Development and validation of a multiwavelength spatial domain near-infrared oximeter to detect cerebral hypoxia-ischemia

Lindsey A. Nelson, John C. McCann, Andreas W. Loepke, Jun Wu, Baruch Ben-Dor, Dean C. Kurth M.D.

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Journal of Biomedical Optics, Vol. 11, Issue 6, 064022 (November 2006). https://doi.org/10.1117/1.2393251

Abstract

Detection of cerebral hypoxia-ischemia in infants remains problematic, as current monitors in clinical practice are impractical, insensitive, or nonspecific. Our study develops a multiwavelength spatial domain construct for near-infrared spectroscopy (NIRS) to detect cerebral hypoxia-ischemia and evaluates the construct in several models. The NIRS probe contains photodiode detectors 2, 3, and 4 cm from a three-wavelength, light-emitting diode. A construct determines cerebral O₂ saturation based on spatial domain principles. Device performance and construct validity are examined in in-vitro models simulating the brain, and in piglets subjected to hypoxia, hypoxia-ischemia, and hyperoxic conditions using a weighted average of arterial and cerebral venous O₂ saturation measured by CO-oximetry. The results in the brain models verify key equations in the construct and demonstrate reliable performance of the device. In piglets, the device measures cerebral O₂ saturation with bias ±4% and precision ±8%. In conclusion, this NIRS device accurately detects cerebral hypoxia-ischemia and is of a design that is practical for clinical application.

©(2006) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Lindsey A. Nelson, John C. McCann, Andreas W. Loepke, Jun Wu, Baruch Ben-Dor, and Dean C. Kurth M.D. "Development and validation of a multiwavelength spatial domain near-infrared oximeter to detect cerebral hypoxia-ischemia," Journal of Biomedical Optics 11(6), 064022 (1 November 2006). https://doi.org/10.1117/1.2393251

Published: 1 November 2006

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