In-vivo singlet oxygen dosimetry of clinical 5-aminolevulinic acid photodynamic therapy

Hans Laubach; Sung K. Chang; Seonkyung Lee; Imran Rizvi; David Zurakowski; Steven J. Davis; Charles R. Taylor; Tayyaba Hasan

doi:10.1117/1.2981813

1 September 2008 In-vivo singlet oxygen dosimetry of clinical 5-aminolevulinic acid photodynamic therapy

Hans Laubach, Sung K. Chang, Seonkyung Lee, Imran Rizvi, David Zurakowski, Steven J. Davis, Charles R. Taylor, Tayyaba Hasan

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Journal of Biomedical Optics, Vol. 13, Issue 5, 050504 (September 2008). https://doi.org/10.1117/1.2981813

Abstract

Photodynamic therapy (PDT) is a viable treatment option for a wide range of applications, including oncology, dermatology, and ophthalmology. Singlet oxygen is believed to play a key role in the efficacy of PDT, and on-line monitoring of singlet oxygen during PDT could provide a methodology to establish and customize the treatment dose clinically. This work is the first report of monitoring singlet oxygen luminescence in vivo in human subjects during PDT, demonstrating the correlation of singlet oxygen levels during PDT with the post-PDT photobiological response.

©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Hans Laubach, Sung K. Chang, Seonkyung Lee, Imran Rizvi, David Zurakowski, Steven J. Davis, Charles R. Taylor, and Tayyaba Hasan "In-vivo singlet oxygen dosimetry of clinical 5-aminolevulinic acid photodynamic therapy," Journal of Biomedical Optics 13(5), 050504 (1 September 2008). https://doi.org/10.1117/1.2981813

Published: 1 September 2008

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