Effect of size of TiO2 nanoparticles applied onto glass slide and porcine skin on generation of free radicals under ultraviolet irradiation

Alexey P. Popov; Stefan Haag; Martina C. Meinke; Jürgen M. Lademann; Alexander V. Priezzhev; Risto A. Myllylä

doi:10.1117/1.3078802

1 March 2009 Effect of size of TiO2 nanoparticles applied onto glass slide and porcine skin on generation of free radicals under ultraviolet irradiation

Alexey P. Popov, Stefan Haag, Martina C. Meinke, Jürgen M. Lademann, Alexander V. Priezzhev, Risto A. Myllylä

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Journal of Biomedical Optics, Vol. 14, Issue 2, 021011 (March 2009). https://doi.org/10.1117/1.3078802

Abstract

Titanium dioxide (TiO2) nanoparticles are extensively used today in sunscreens and coatings as protective compounds for human skin and material surfaces from UV radiation. In this paper, such particles are investigated by electron paramagnetic resonance spectroscopy as sources of free radicals under UV irradiation. The surface density of a placebo with embedded particles corresponds to the recommendations of dermatologists (2 mg cm−2). It is revealed that if applied onto glass, small particles 25 nm in diameter produce an increased amount of free radicals compared to the larger ones of 400 nm diam and the placebo itself. However, if applied onto porcine skin in vitro, there is no statistically distinct difference in the amount of radicals generated by the two kinds of particles on skin and by the skin itself. This proves that although particles as part of sunscreens produce free radicals, the effect is negligible in comparison to the production of radicals by skin in vitro.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Alexey P. Popov, Stefan Haag, Martina C. Meinke, Jürgen M. Lademann, Alexander V. Priezzhev, and Risto A. Myllylä "Effect of size of TiO2 nanoparticles applied onto glass slide and porcine skin on generation of free radicals under ultraviolet irradiation," Journal of Biomedical Optics 14(2), 021011 (1 March 2009). https://doi.org/10.1117/1.3078802

Published: 1 March 2009

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