Characterizing liquid turbid media by frequency-domain photon-migration spectroscopy

Biju Cletus; Rainer Kunnemeyer; Paul Martinsen; Andrew McGlone; Robert Jordan

doi:10.1117/1.3119282

1 March 2009 Characterizing liquid turbid media by frequency-domain photon-migration spectroscopy

Biju Cletus, Rainer Kunnemeyer, Paul Martinsen, Andrew McGlone, Robert Jordan

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Journal of Biomedical Optics, Vol. 14, Issue 2, 024041 (March 2009). https://doi.org/10.1117/1.3119282

Abstract

We present a wavelength-tunable frequency-domain instrument for the characterization of liquid turbid media. The instrument employs a tunable titanium-sapphire laser modulated by an acousto-optic modulator. The absorption and reduced scattering coefficient of Intralipid® 20%, diluted to concentrations of 0.94 to 4.00%, are measured over the wavelength range 710 to 850 nm at 10-nm intervals. The standard measurement errors for the absorption and reduced scattering coefficients are 1 and 2.5%, respectively. Extrapolation to 0% Intralipid® concentration gives an absorption coefficient that closely follows that of water, overestimating the absorption of pure water by less than 10%. The reduced scattering coefficient is compared at 750 nm with published results and is found consistent within the experimental error. We compare the reduced scattering coefficient to an estimate based on Mie theory and find the reduced scattering coefficient underestimated the Mie theory result by about 9%.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Biju Cletus, Rainer Kunnemeyer, Paul Martinsen, Andrew McGlone, and Robert Jordan "Characterizing liquid turbid media by frequency-domain photon-migration spectroscopy," Journal of Biomedical Optics 14(2), 024041 (1 March 2009). https://doi.org/10.1117/1.3119282

Published: 1 March 2009

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KEYWORDS

Mie scattering

Scattering

Absorption

Liquids

Modulation

Particles

Optical properties

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