Intraluminal fluorescence spectroscopy catheter with ultrasound guidance

Douglas N. Stephens; Jesung Park; Yang Sun; Thanassis Papaioannou; Laura Marcu

doi:10.1117/1.3146813

1 May 2009 Intraluminal fluorescence spectroscopy catheter with ultrasound guidance

Douglas N. Stephens, Jesung Park, Yang Sun, Thanassis Papaioannou, Laura Marcu

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Journal of Biomedical Optics, Vol. 14, Issue 3, 030505 (May 2009). https://doi.org/10.1117/1.3146813

Abstract

We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53±0.16 mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Douglas N. Stephens, Jesung Park, Yang Sun, Thanassis Papaioannou, and Laura Marcu "Intraluminal fluorescence spectroscopy catheter with ultrasound guidance," Journal of Biomedical Optics 14(3), 030505 (1 May 2009). https://doi.org/10.1117/1.3146813

Published: 1 May 2009

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KEYWORDS

Intravascular ultrasound

Blood

Arteries

Optical fibers

Luminescence

Prototyping

Fluorescence spectroscopy

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