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1 May 2009 Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds
Yali Jia, Pierre-Olivier Bagnaninchi, Ying Yang, Alicia J. El Haj, Monica T. Hinds, Sean J. Kirkpatrick, Ruikang Wang
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Journal of Biomedical Optics, Vol. 14, Issue 3, 034014 (May 2009). https://doi.org/10.1117/1.3130345
Abstract
Establishing a relationship between perfusion rate and fluid shear stress in a 3D cell culture environment is an ongoing and challenging task faced by tissue engineers. We explore Doppler optical coherence tomography (DOCT) as a potential imaging tool for in situ monitoring of local fluid flow profiles inside porous chitosan scaffolds. From the measured fluid flow profiles, the fluid shear stresses are evaluated. We examine the localized fluid flow and shear stress within low- and high-porosity chitosan scaffolds, which are subjected to a constant input flow rate of 0.5 ml·min-1. The DOCT results show that the behavior of the fluid flow and shear stress in micropores is strongly dependent on the micropore interconnectivity, porosity, and size of pores within the scaffold. For low-porosity and high-porosity chitosan scaffolds examined, the measured local fluid flow and shear stress varied from micropore to micropore, with a mean shear stress of 0.49±0.3 dyn·cm-2 and 0.38±0.2 dyn·cm-2, respectively. In addition, we show that the scaffold's porosity and interconnectivity can be quantified by combining analyses of the 3D structural and flow images obtained from DOCT.
©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Yali Jia, Pierre-Olivier Bagnaninchi, Ying Yang, Alicia J. El Haj, Monica T. Hinds, Sean J. Kirkpatrick, and Ruikang Wang "Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds," Journal of Biomedical Optics 14(3), 034014 (1 May 2009). https://doi.org/10.1117/1.3130345
Published: 1 May 2009
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Cited by 27 scholarly publications.
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KEYWORDS
Optical coherence tomography
Microfluidics
Microfluidic imaging
Coherence imaging
Doppler tomography
Tissues
3D image processing
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