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1 September 2009 Simultaneous, noninvasive observation of elastic scattering, fluorescence and inelastic scattering as a monitor of blood flow and hematocrit in human fingertip capillary beds
Joseph Chaiken, Jerry Goodisman, Bin Deng, Rebecca Jane Bussjaeger, George Shaheen
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Journal of Biomedical Optics, Vol. 14, Issue 5, 050505 (September 2009). https://doi.org/10.1117/1.3233629
Abstract
We report simultaneous observation of elastic scattering, fluorescence, and inelastic scattering from in vivo near-infrared probing of human skin. Careful control of the mechanical force needed to obtain reliable registration of in vivo tissue with an appropriate optical system allows reproducible observation of blood flow in capillary beds of human volar side fingertips. The time dependence of the elastically scattered light is highly correlated with that of the combined fluorescence and Raman scattered light. We interpret this in terms of turbidity (the impeding effect of red blood cells on optical propagation to and from the scattering centers) and the changes in the volume percentages of the tissues in the irradiated volume with normal homeostatic processes. By fitting to a model, these measurements may be used to determine volume fractions of plasma and RBCs.
©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Joseph Chaiken, Jerry Goodisman, Bin Deng, Rebecca Jane Bussjaeger, and George Shaheen "Simultaneous, noninvasive observation of elastic scattering, fluorescence and inelastic scattering as a monitor of blood flow and hematocrit in human fingertip capillary beds," Journal of Biomedical Optics 14(5), 050505 (1 September 2009). https://doi.org/10.1117/1.3233629
Published: 1 September 2009
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Cited by 29 scholarly publications and 2 patents.
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KEYWORDS
Light scattering
Scattering
Plasma
Luminescence
Capillaries
Tissue optics
Skin
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