In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography

Jiechen Yin; Gangjun Liu; Jun Zhang; Lingfeng Yu; Sari B. Mahon; David Sho Mukai; Matthew Brenner M.D.; Zhongping Chen

doi:10.1117/1.3268775

1 November 2009 In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography

Jiechen Yin, Gangjun Liu, Jun Zhang, Lingfeng Yu, Sari B. Mahon, David Sho Mukai, Matthew Brenner M.D., Zhongping Chen

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Journal of Biomedical Optics, Vol. 14, Issue 6, 060503 (November 2009). https://doi.org/10.1117/1.3268775

Abstract

We report on the feasibility of rapid, high-resolution, 3-D swept-source optical coherence tomography (SSOCT) to detect early airway injury changes following smoke inhalation exposure in a rabbit model. The SSOCT system obtains 3-D helical scanning using a microelectromechanical system motor-based endoscope. Real-time 2-D data processing and image display at the speed of 20 frames/s are achieved by adopting the technique of parallel computing. Longitudinal images are reconstructed via an image processing algorithm to remove motion artifacts caused by ventilation and pulse. Quantitative analyses of tracheal airway thickness as well as thickness distribution along tracheal circumference are also performed based on the comprehensive 3-D volumetric data.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Jiechen Yin, Gangjun Liu, Jun Zhang, Lingfeng Yu, Sari B. Mahon, David Sho Mukai, Matthew Brenner M.D., and Zhongping Chen "In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography," Journal of Biomedical Optics 14(6), 060503 (1 November 2009). https://doi.org/10.1117/1.3268775

Published: 1 November 2009

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