Whole-body, real-time preclinical imaging of quantum dot fluorescence with time-gated detection

Andrzej May; Srabani Bhaumik; Sanjiv Sam Gambhir; Chun Zhan; Siavash Yazdanfar

doi:10.1117/1.3269675

1 November 2009 Whole-body, real-time preclinical imaging of quantum dot fluorescence with time-gated detection

Andrzej May, Srabani Bhaumik, Sanjiv Sam Gambhir, Chun Zhan, Siavash Yazdanfar

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Journal of Biomedical Optics, Vol. 14, Issue 6, 060504 (November 2009). https://doi.org/10.1117/1.3269675

Abstract

We describe a wide-field preclinical imaging system optimized for time-gated detection of quantum dot fluorescence emission. As compared to continuous wave measurements, image contrast was substantially improved by suppression of short-lifetime background autofluorescence. Real-time (8 frames/s) biological imaging of subcutaneous quantum dot injections is demonstrated simultaneously in multiple living mice.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Andrzej May, Srabani Bhaumik, Sanjiv Sam Gambhir, Chun Zhan, and Siavash Yazdanfar "Whole-body, real-time preclinical imaging of quantum dot fluorescence with time-gated detection," Journal of Biomedical Optics 14(6), 060504 (1 November 2009). https://doi.org/10.1117/1.3269675

Published: 1 November 2009

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