Whole-body three-dimensional optoacoustic tomography system for small animals

Hans-Peter F. Brecht; Richard Su; Matthew P. Fronheiser; Sergey A. Ermilov; André Conjusteau; Alexander A. Oraevsky

doi:10.1117/1.3259361

1 November 2009 Whole-body three-dimensional optoacoustic tomography system for small animals

Hans-Peter F. Brecht, Richard Su, Matthew P. Fronheiser, Sergey A. Ermilov, André Conjusteau, Alexander A. Oraevsky

Author Affiliations +

Journal of Biomedical Optics, Vol. 14, Issue 6, 064007 (November 2009). https://doi.org/10.1117/1.3259361

Abstract

We develop a system for three-dimensional whole-body optoacoustic tomography of small animals for applications in preclinical research. The tomographic images are obtained while the objects of study (phantoms or mice) are rotated within a sphere outlined by a concave arc-shaped array of 64 piezocomposite transducers. Two pulsed lasers operating in the near-IR spectral range (755 and 1064 nm) with an average pulsed energy of about 100 mJ, a repetition rate of 10 Hz, and a pulse duration of 15 to 75 ns are used as optical illumination sources. During the scan, the mouse is illuminated orthogonally to the array with two wide beams of light from a bifurcated fiber bundle. The system is capable of generating images of individual organs and blood vessels through the entire body of a mouse with spatial resolution of ~0.5 mm.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Hans-Peter F. Brecht, Richard Su, Matthew P. Fronheiser, Sergey A. Ermilov, André Conjusteau, and Alexander A. Oraevsky "Whole-body three-dimensional optoacoustic tomography system for small animals," Journal of Biomedical Optics 14(6), 064007 (1 November 2009). https://doi.org/10.1117/1.3259361

Published: 1 November 2009

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KEYWORDS

Tomography

Transducers

3D image processing

Imaging systems

Opacity

Veins

Video

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