Mechanical tissue optical clearing devices: evaluation of enhanced light penetration in skin using optical coherence tomography

Chris Drew; Thomas E. Milner; Christopher G. Rylander

doi:10.1117/1.3268441

1 November 2009 Mechanical tissue optical clearing devices: evaluation of enhanced light penetration in skin using optical coherence tomography

Chris Drew, Thomas E. Milner, Christopher G. Rylander

Author Affiliations +

Journal of Biomedical Optics, Vol. 14, Issue 6, 064019 (November 2009). https://doi.org/10.1117/1.3268441

Abstract

We report results of a study to evaluate effectiveness of a mechanical tissue optical clearing device (TOCD) using optical coherence tomography (OCT). The TOCD uses a pin array and vacuum pressure source to compress localized regions of the skin surface. OCT images (850 and 1310 nm) of in vivo human skin indicate application of the TOCD provides an up to threefold increased light penetration depth at spatial positions correlated with pin indentations. Increased contrast of the epidermal-dermal junction in OCT images spatially correlates with indented zones. OCT M-scans recorded while applying the TOCD indicate optical penetration depth monotonically increased, with most improvement at early times (5 to 10 s) of TOCD vacuum application. OCT M-scans of ex vivo porcine skin compressed using the TOCD suggest average group refractive index of the tissue increased, corresponding to a decrease in water concentration. Results of our study indicate that mechanical optical clearing of skin may provide an effective and efficient means to deliver increased light fluence to dermal and subdermal regions.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

Chris Drew, Thomas E. Milner, and Christopher G. Rylander "Mechanical tissue optical clearing devices: evaluation of enhanced light penetration in skin using optical coherence tomography," Journal of Biomedical Optics 14(6), 064019 (1 November 2009). https://doi.org/10.1117/1.3268441

Published: 1 November 2009

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

CITATIONS

Cited by 42 scholarly publications.

Explore citations on Lens.org

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Skin

Optical coherence tomography

Tissue optics

Water

Light scattering

Tissues

Refractive index

Show All Keywords

RELATED CONTENT

In-vivo evaluation of locally mapped refractive indices with OCT
Proceedings of SPIE (May 23 2001)

Tissue clearing of biotissues for optical coherence tomography
Proceedings of SPIE (September 12 2002)

Mechanism for tissue optical clearing: physical and physiological research
Proceedings of SPIE (April 12 2011)

Effect of dehydration on optical clearing and OCT imaging contrast...
Proceedings of SPIE (July 01 2004)

Mechanical tissue optical clearing devices evaluation of enhanced light...
Proceedings of SPIE (February 24 2009)

Fundamentals and developments of biological tissue optical clearing
Proceedings of SPIE (October 27 2006)

Subscribe to Digital Library

Receive Erratum Email Alert

Show All Keywords

Keywords/Phrases

Search In:

Publication Years