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22 February 2012 Normal and system lupus erythematosus red blood cell interactions studied by double trap optical tweezers: direct measurements of aggregation forces
Maria Khokhlova, Eugeny V. Lyubin, Alexander G. Zhdanov, Andrey A. Fedyanin, Sophia Yu. Rykova, Irina A. Sokolova
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Journal of Biomedical Optics, Vol. 17, Issue 2, 025001 (February 2012). https://doi.org/10.1117/1.JBO.17.2.025001
Abstract
Direct measurements of aggregation forces in piconewton range between two red blood cells in pair rouleau are performed under physiological conditions using double trap optical tweezers. Aggregation and disaggregation properties of healthy and pathologic (system lupus erythematosis) blood samples are analyzed. Strong difference in aggregation speed and behavior is revealed using the offered method which is proposed to be a promising tool for SLE monitoring at single cell level.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
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Maria Khokhlova, Eugeny V. Lyubin, Alexander G. Zhdanov, Andrey A. Fedyanin, Sophia Yu. Rykova, and Irina A. Sokolova "Normal and system lupus erythematosus red blood cell interactions studied by double trap optical tweezers: direct measurements of aggregation forces," Journal of Biomedical Optics 17(2), 025001 (22 February 2012). https://doi.org/10.1117/1.JBO.17.2.025001
Published: 22 February 2012
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KEYWORDS
Blood
Optical tweezers
Plasma
Calibration
Statistical analysis
Optical testing
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