Ultrasound-modulated optical tomography at new depth

Puxiang Lai; Xiao Xu; Lihong V. Wang

doi:10.1117/1.JBO.17.6.066006

4 June 2012 Ultrasound-modulated optical tomography at new depth

Puxiang Lai, Xiao Xu, Lihong V. Wang

Author Affiliations +

Journal of Biomedical Optics, Vol. 17, Issue 6, 066006 (June 2012). https://doi.org/10.1117/1.JBO.17.6.066006

Abstract

Ultrasound-modulated optical tomography (UOT) has the potential to reveal optical contrast deep inside soft biological tissues at an ultrasonically determined spatial resolution. The optical imaging depth reported so far has, however, been limited, which prevents this technique from broader applications. Our latest experimental exploration has pushed UOT to an unprecedented imaging depth. We developed and optimized a UOT system employing a photorefractive crystal-based interferometer. A large aperture optical fiber bundle was used to enhance the efficiencies for diffuse light collection and photorefractive two-wave-mixing. Within the safety limits for both laser illumination and ultrasound modulation, the system has attained the ability to image through a tissue-mimicking phantom of 9.4 cm in thickness, which has never been reached previously by UOT.

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Puxiang Lai, Xiao Xu, and Lihong V. Wang "Ultrasound-modulated optical tomography at new depth," Journal of Biomedical Optics 17(6), 066006 (4 June 2012). https://doi.org/10.1117/1.JBO.17.6.066006

Received: 7 March 2012; Accepted: 10 April 2012; Published: 4 June 2012

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KEYWORDS

Ultrasonography

Modulation

Ultrasound-modulated optical tomography

Tissues

Tissue optics

Crystals

Absorption

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