Retina-simulating phantom for optical coherence tomography

Jigesh Baxi; William R. Calhoun III; Yasir J. Sepah; Daniel X. Hammer; Ilko Ilev; T. Joshua Pfefer; Quan Dong Nguyen; Anant Agrawal

doi:10.1117/1.JBO.19.2.021106

16 September 2013 Retina-simulating phantom for optical coherence tomography

Jigesh Baxi, William R. Calhoun III, Yasir J. Sepah, Daniel X. Hammer, Ilko Ilev, T. Joshua Pfefer, Quan Dong Nguyen, Anant Agrawal

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Journal of Biomedical Optics, Vol. 19, Issue 2, 021106 (September 2013). https://doi.org/10.1117/1.JBO.19.2.021106

Abstract

Optical coherence tomography (OCT) is a rapidly growing imaging modality, particularly in the field of ophthalmology. Accurate early diagnosis of diseases requires consistent and validated imaging performance. In contrast to more well-established medical imaging modalities, no standardized test methods currently exist for OCT quality assurance. We developed a retinal phantom which mimics the thickness and near-infrared optical properties of each anatomical retinal layer as well as the surface topography of the foveal pit. The fabrication process involves layer-by-layer spin coating of nanoparticle-embedded silicone films followed by laser micro-etching to modify the surface topography. The thickness of each layer and dimensions of the foveal pit are measured with high precision. The phantom is embedded into a commercially available, water-filled model eye to simulate ocular dispersion and emmetropic refraction, and for ease of use with clinical OCT systems. The phantom was imaged with research and clinical OCT systems to assess image quality and software accuracy. Our results indicate that this phantom may serve as a useful tool to evaluate and standardize OCT performance.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Jigesh Baxi, William R. Calhoun III, Yasir J. Sepah, Daniel X. Hammer, Ilko Ilev, T. Joshua Pfefer, Quan Dong Nguyen, and Anant Agrawal "Retina-simulating phantom for optical coherence tomography," Journal of Biomedical Optics 19(2), 021106 (16 September 2013). https://doi.org/10.1117/1.JBO.19.2.021106

Published: 16 September 2013

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