Differential diagnosis of breast masses in South Korean premenopausal women using diffuse optical spectroscopic imaging

Anaïs Leproux; You Me Kim; Jun Won Min; Christine E. McLaren; Wen-Pin Chen; Thomas D. O'Sullivan; Seung-ha Lee; Phil-Sang Chung; Bruce J. Tromberg

doi:10.1117/1.JBO.21.7.074001

20 July 2016 Differential diagnosis of breast masses in South Korean premenopausal women using diffuse optical spectroscopic imaging

Anaïs Leproux, You Me Kim, Jun Won Min, Christine E. McLaren, Wen-Pin Chen, Thomas D. O'Sullivan, Seung-ha Lee, Phil-Sang Chung, Bruce J. Tromberg

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Journal of Biomedical Optics, Vol. 21, Issue 7, 074001 (July 2016). https://doi.org/10.1117/1.JBO.21.7.074001

Abstract

Young patients with dense breasts have a relatively low-positive biopsy rate for breast cancer (∼1 in 7). South Korean women have higher breast density than Westerners. We investigated the benefit of using a functional and metabolic imaging technique, diffuse optical spectroscopic imaging (DOSI), to help the standard of care imaging tools to distinguish benign from malignant lesions in premenopausal Korean women. DOSI uses near-infrared light to measure breast tissue composition by quantifying tissue concentrations of water (ctH₂O), bulk lipid (ctLipid), deoxygenated (ctHHb), and oxygenated (ctHbO₂) hemoglobin. DOSI spectral signatures specific to abnormal tissue and absent in healthy tissue were also used to form a malignancy index. This study included 19 premenopausal subjects (average age 41±9), corresponding to 11 benign and 10 malignant lesions. Elevated lesion to normal ratio of ctH₂O, ctHHb, ctHbO₂, total hemoglobin (THb=ctHHb+ctHbO₂), and tissue optical index (ctHHb×ctH₂O/ctLipid) were observed in the malignant lesions compared to the benign lesions (p<0.02). THb and malignancy index were the two best single predictors of malignancy, with >90% sensitivity and specificity. Malignant lesions showed significantly higher metabolism and perfusion than benign lesions. DOSI spectral features showed high discriminatory power for distinguishing malignant and benign lesions in dense breasts of the Korean population.

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Anaïs Leproux, You Me Kim, Jun Won Min, Christine E. McLaren, Wen-Pin Chen, Thomas D. O'Sullivan, Seung-ha Lee, Phil-Sang Chung, and Bruce J. Tromberg "Differential diagnosis of breast masses in South Korean premenopausal women using diffuse optical spectroscopic imaging," Journal of Biomedical Optics 21(7), 074001 (20 July 2016). https://doi.org/10.1117/1.JBO.21.7.074001

Published: 20 July 2016

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